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Researchers develop AI-based Platform to Rapidly find Age-defying Molecules

Researchers at the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi) have unveiled AgeXtend, a revolutionary AI-powered platform aimed at discovering molecules that slow down aging and promote healthier living. This significant breakthrough, published in the journal Nature Aging, positions India as a leader in anti-aging research.

Key Features of AgeXtend

  • Data-Driven Predictions:
    • AgeXtend uses bioactivity data from existing geroprotectors (substances known to slow aging) to predict new molecules with similar properties.
  • Comprehensive Screening:
    • The platform has analyzed over 1.1 billion compounds, identifying numerous promising candidates.
  • Safety and Mechanistic Insights:
    • AI modules assess:
      • Geroprotective potential: Likelihood of slowing aging.
      • Toxicity: Ensuring the safety of molecules.
      • Target Proteins and Mechanisms: Understanding how molecules act in the body.

Testing and Results

  • AgeXtend’s capabilities were validated by excluding well-known compounds like metformin and taurine, which are already associated with longevity. The platform accurately predicted their benefits, showcasing its reliability.
  • Promising candidates were tested on:
    • Yeast
    • C. elegans (tiny worms)
    • Human cells
  • Special experiments on human cells confirmed AgeXtend’s ability to identify effective anti-aging substances.

Innovative Capabilities

  • Microbiome Analysis:
    • AgeXtend also explores natural compounds found in the human microbiome, studying their role in controlling cellular aging.
  • Target Identification:
    • By identifying proteins and mechanisms associated with aging, the platform helps refine drug discovery processes for longevity.

Significance of AgeXtend

  • Revolutionizing Longevity Science:
    • By combining AI with biology, AgeXtend accelerates the discovery of safe and effective anti-aging molecules.
  • Tackling Age-Related Diseases:
    • The platform opens doors to treatments for age-related diseases like Alzheimer’s, diabetes, and cardiovascular ailments.
  • Cost-Effective Research:
    • AgeXtend reduces time and costs associated with traditional drug discovery methods.

Conclusion

AgeXtend is a groundbreaking innovation in the fight against aging. Its ability to predict, validate, and ensure the safety of anti-aging compounds establishes a new standard in longevity research, offering hope for healthier and longer lives.

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I, Sakshi Gupta, am a content writer to empower students aiming for UPSC, PSC, and other competitive exams. My objective is to provide clear, concise, and informative content that caters to your exam preparation needs. I strive to make my content not only informative but also engaging, keeping you motivated throughout your journey!