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Researchers at the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi) have unveiled AgeXtend, a revolutionary AI-powered platform aimed at discovering molecules that slow down aging and promote healthier living. This significant breakthrough, published in the journal Nature Aging, positions India as a leader in anti-aging research.
Key Features of AgeXtend
- Data-Driven Predictions:
- AgeXtend uses bioactivity data from existing geroprotectors (substances known to slow aging) to predict new molecules with similar properties.
- Comprehensive Screening:
- The platform has analyzed over 1.1 billion compounds, identifying numerous promising candidates.
- Safety and Mechanistic Insights:
- AI modules assess:
- Geroprotective potential: Likelihood of slowing aging.
- Toxicity: Ensuring the safety of molecules.
- Target Proteins and Mechanisms: Understanding how molecules act in the body.
- AI modules assess:
Testing and Results
- AgeXtend’s capabilities were validated by excluding well-known compounds like metformin and taurine, which are already associated with longevity. The platform accurately predicted their benefits, showcasing its reliability.
- Promising candidates were tested on:
- Yeast
- C. elegans (tiny worms)
- Human cells
- Special experiments on human cells confirmed AgeXtend’s ability to identify effective anti-aging substances.
Innovative Capabilities
- Microbiome Analysis:
- AgeXtend also explores natural compounds found in the human microbiome, studying their role in controlling cellular aging.
- Target Identification:
- By identifying proteins and mechanisms associated with aging, the platform helps refine drug discovery processes for longevity.
Significance of AgeXtend
- Revolutionizing Longevity Science:
- By combining AI with biology, AgeXtend accelerates the discovery of safe and effective anti-aging molecules.
- Tackling Age-Related Diseases:
- The platform opens doors to treatments for age-related diseases like Alzheimer’s, diabetes, and cardiovascular ailments.
- Cost-Effective Research:
- AgeXtend reduces time and costs associated with traditional drug discovery methods.
Conclusion
AgeXtend is a groundbreaking innovation in the fight against aging. Its ability to predict, validate, and ensure the safety of anti-aging compounds establishes a new standard in longevity research, offering hope for healthier and longer lives.