Researchers develop AI-based Platform to Rapidly find Age-defying Molecules

Researchers at the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi) have unveiled AgeXtend, a revolutionary AI-powered platform aimed at discovering molecules that slow down aging and promote healthier living. This significant breakthrough, published in the journal Nature Aging, positions India as a leader in anti-aging research.

Key Features of AgeXtend

• Data-Driven Predictions:
  • AgeXtend uses bioactivity data from existing geroprotectors (substances known to slow aging) to predict new molecules with similar properties.
• Comprehensive Screening:
  • The platform has analyzed over 1.1 billion compounds, identifying numerous promising candidates.
• Safety and Mechanistic Insights:
  • AI modules assess:
    • Geroprotective potential: Likelihood of slowing aging.
    • Toxicity: Ensuring the safety of molecules.
    • Target Proteins and Mechanisms: Understanding how molecules act in the body.

Testing and Results

• AgeXtend’s capabilities were validated by excluding well-known compounds like metformin and taurine, which are already associated with longevity. The platform accurately predicted their benefits, showcasing its reliability.
• Promising candidates were tested on:
  • Yeast
  • C. elegans (tiny worms)
  • Human cells
• Special experiments on human cells confirmed AgeXtend’s ability to identify effective anti-aging substances.

Innovative Capabilities

• Microbiome Analysis:
  • AgeXtend also explores natural compounds found in the human microbiome, studying their role in controlling cellular aging.
• Target Identification:
  • By identifying proteins and mechanisms associated with aging, the platform helps refine drug discovery processes for longevity.

Significance of AgeXtend

• Revolutionizing Longevity Science:
  • By combining AI with biology, AgeXtend accelerates the discovery of safe and effective anti-aging molecules.
• Tackling Age-Related Diseases:
  • The platform opens doors to treatments for age-related diseases like Alzheimer’s, diabetes, and cardiovascular ailments.
• Cost-Effective Research:
  • AgeXtend reduces time and costs associated with traditional drug discovery methods.

Conclusion

AgeXtend is a groundbreaking innovation in the fight against aging. Its ability to predict, validate, and ensure the safety of anti-aging compounds establishes a new standard in longevity research, offering hope for healthier and longer lives.

Sharing is caring!